Package: goldilocks 0.5.0.9000

Overview | Function dependency diagram | Function roles | Simulation layer | Post-processing functions | Data generation and analysis utilities

The decision rule | Setting up the design | Operating characteristics | A practical caveat on benchmarks | See also

Vignette summary | 1. Design and notation | 2. Continuous-time enrollment process | 3. Event-time model | 4. Posterior distribution of hazards | $$\pi(\boldsymbol{\lambda} \mid \mathcal{D}) | 5. Predictive distribution for incomplete outcomes | $$p(\mathcal{D}^{\mathrm{mis}} \mid \mathcal{D}_{\ell}^{\mathrm{obs}}) | 6. Interim decision algorithm | 5.1 Predictive probability at the current sample size | $$P_ | 5.2 Predictive probability at the maximum sample size | $$P_ | 7. Final analysis | 6.1 Frequentist final tests | 6.2 Bayesian survival final test | $$\Delta^ | \left[1 - \exp{-H_1^{(b)}(\tau)}\right] | $$\widehat{\Pr}(\Delta < h_0 \mid \mathcal{D}) | 6.3 Bayesian binary final test | 6.4 Loss to follow-up at the final analysis | 8. Operating characteristics | 7.1 Visual diagnostics | 9. Threshold selection | 10. Relation to group-sequential designs | 11. Package-specific scope | References

One-sided tests | References

Two-arm design | Choosing the binary imputation approach | Single-arm design | Choosing bin_method | Operating characteristics

Trial overview | The Goldilocks flow | Endpoint scale | SAP event-time models and time units | Effectiveness endpoint | Safety endpoint | A compact design object | Visualizing the simulated design | A fuller simulation template | SAP sensitivity assumptions and reference benchmarks | References

When piecewise hazards help | Setting up the design | The Bayesian decision rule | What a simulated trial dataset looks like | A single simulated trial | Notes on the piecewise model | Sensitivity to the cut-point specification | See also

A traced trial | Visualizing the path | Summarizing many simulated trials