Package: joineRML
Type: Package
Title: Joint Modelling of Multivariate Longitudinal Data and
        Time-to-Event Outcomes
Version: 0.4.8
Authors@R: c(
    person("Graeme L.", "Hickey", email = "graemeleehickey@gmail.com", 
        role = c("cre", "aut"),
        comment = c(ORCID = "0000-0002-4989-0054")),
    person("Pete", "Philipson", email = "peter.philipson1@newcastle.ac.uk", 
        role = "aut",
        comment = c(ORCID = "0000-0001-7846-0208")),
    person("Andrea", "Jorgensen", email = "aljorgen@liverpool.ac.uk", 
        role = "ctb",
        comment = c(ORCID = "0000-0002-6977-9337")),
    person("Ruwanthi", "Kolamunnage-Dona", email = "kdrr@liverpool.ac.uk", 
        role = "aut",
        comment = c(ORCID = "0000-0003-3886-6208")),
    person("Paula", "Williamson", email = "p.r.williamson@liverpool.ac.uk",
        role = "ctb",
        comment = c(ORCID = "0000-0001-9802-6636")),
    person("Dimitris", "Rizopoulos", email = "d.rizopoulos@erasmusmc.nl",
        role = c("ctb", "dtc"),
        comment = "data/renal.rda, R/hessian.R, R/vcov.R"),
    person("Alessandro", "Gasparini", email = "alessandro.gasparini@ki.se",
        role = "aut",
        comment = c(ORCID = "0000-0002-8319-7624")),
    person("Medical Research Council", role = "fnd",
        comment = "Grant number: MR/M013227/1")
    )
Encoding: UTF-8
Description: Fits the joint model proposed by Henderson and colleagues
        (2000) <doi:10.1093/biostatistics/1.4.465>, but extended to the
        case of multiple continuous longitudinal measures. The
        time-to-event data is modelled using a Cox proportional hazards
        regression model with time-varying covariates. The multiple
        longitudinal outcomes are modelled using a multivariate version
        of the Laird and Ware linear mixed model. The association is
        captured by a multivariate latent Gaussian process. The model
        is estimated using a Monte Carlo Expectation Maximization
        algorithm. This project was funded by the Medical Research
        Council (Grant number MR/M013227/1).
License: GPL-3 | file LICENSE
URL: https://graemeleehickey.github.io/joineRML/,
        https://github.com/graemeleehickey/joineRML,
        https://CRAN.R-project.org/package=joineRML
BugReports: https://github.com/graemeleehickey/joineRML/issues
LazyData: true
Depends: R (>= 4.1.0), nlme, survival
Imports: cobs, doParallel, foreach, generics, ggplot2, graphics, lme4
        (>= 1.1-8), MASS, Matrix, mvtnorm, parallel, randtoolbox, Rcpp
        (>= 0.12.7), RcppArmadillo, stats, tibble, utils
LinkingTo: Rcpp, RcppArmadillo
RoxygenNote: 7.3.3
Suggests: dplyr, JM, joineR, knitr, pkgdown, rmarkdown, testthat (>=
        3.0.0)
VignetteBuilder: knitr
Config/testthat/edition: 3
Config/pak/sysreqs: cmake make
Repository: https://graemeleehickey.r-universe.dev
Date/Publication: 2026-06-13 20:03:39 UTC
RemoteUrl: https://github.com/graemeleehickey/joinerml
RemoteRef: HEAD
RemoteSha: 451eadcc56441fea0d9242c78dac12a11ca49184
NeedsCompilation: yes
Packaged: 2026-06-13 21:16:29 UTC; root
Author: Graeme L. Hickey [cre, aut] (ORCID:
    <https://orcid.org/0000-0002-4989-0054>),
  Pete Philipson [aut] (ORCID: <https://orcid.org/0000-0001-7846-0208>),
  Andrea Jorgensen [ctb] (ORCID: <https://orcid.org/0000-0002-6977-9337>),
  Ruwanthi Kolamunnage-Dona [aut] (ORCID:
    <https://orcid.org/0000-0003-3886-6208>),
  Paula Williamson [ctb] (ORCID: <https://orcid.org/0000-0001-9802-6636>),
  Dimitris Rizopoulos [ctb, dtc] (data/renal.rda, R/hessian.R, R/vcov.R),
  Alessandro Gasparini [aut] (ORCID:
    <https://orcid.org/0000-0002-8319-7624>),
  Medical Research Council [fnd] (Grant number: MR/M013227/1)
Maintainer: Graeme L. Hickey <graemeleehickey@gmail.com>