{ "_id": "6a2137efcd65a98ecbd27151", "Package": "joineRML", "Type": "Package", "Title": "Joint Modelling of Multivariate Longitudinal Data and\nTime-to-Event Outcomes", "Version": "0.4.7", "Authors@R": "c(\nperson(\"Graeme L.\", \"Hickey\", email = \"graemeleehickey@gmail.com\",\nrole = c(\"cre\", \"aut\"),\ncomment = c(ORCID = \"0000-0002-4989-0054\")),\nperson(\"Pete\", \"Philipson\", email = \"peter.philipson1@newcastle.ac.uk\",\nrole = \"aut\",\ncomment = c(ORCID = \"0000-0001-7846-0208\")),\nperson(\"Andrea\", \"Jorgensen\", email = \"aljorgen@liverpool.ac.uk\",\nrole = \"ctb\",\ncomment = c(ORCID = \"0000-0002-6977-9337\")),\nperson(\"Ruwanthi\", \"Kolamunnage-Dona\", email = \"kdrr@liverpool.ac.uk\",\nrole = \"aut\",\ncomment = c(ORCID = \"0000-0003-3886-6208\")),\nperson(\"Paula\", \"Williamson\", email = \"p.r.williamson@liverpool.ac.uk\",\nrole = \"ctb\",\ncomment = c(ORCID = \"0000-0001-9802-6636\")),\nperson(\"Dimitris\", \"Rizopoulos\", email = \"d.rizopoulos@erasmusmc.nl\",\nrole = c(\"ctb\", \"dtc\"),\ncomment = \"data/renal.rda, R/hessian.R, R/vcov.R\"),\nperson(\"Alessandro\", \"Gasparini\", email = \"alessandro.gasparini@ki.se\",\nrole = \"aut\",\ncomment = c(ORCID = \"0000-0002-8319-7624\")),\nperson(\"Medical Research Council\", role = \"fnd\",\ncomment = \"Grant number: MR/M013227/1\")\n)", "Encoding": "UTF-8", "Description": "Fits the joint model proposed by Henderson and colleagues\n(2000) , but extended to the\ncase of multiple continuous longitudinal measures. The\ntime-to-event data is modelled using a Cox proportional hazards\nregression model with time-varying covariates. The multiple\nlongitudinal outcomes are modelled using a multivariate version\nof the Laird and Ware linear mixed model. The association is\ncaptured by a multivariate latent Gaussian process. The model\nis estimated using a Monte Carlo Expectation Maximization\nalgorithm. This project was funded by the Medical Research\nCouncil (Grant number MR/M013227/1).", "License": "GPL-3 | file LICENSE", "URL": "https://github.com/graemeleehickey/joineRML", "BugReports": "https://github.com/graemeleehickey/joineRML/issues", "LazyData": "true", "RoxygenNote": "7.3.2", "VignetteBuilder": "knitr", "Config/pak/sysreqs": "cmake make", "Repository": "https://graemeleehickey.r-universe.dev", "Date/Publication": "2025-02-04 15:52:49 UTC", "RemoteUrl": "https://github.com/graemeleehickey/joinerml", "RemoteRef": "HEAD", "RemoteSha": "5c68c4f5bf52118ea3eaf82965e462becda32deb", "NeedsCompilation": "yes", "Packaged": { "Date": "2026-06-04 08:20:40 UTC", "User": "root" }, "Author": "Graeme L. Hickey [cre, aut] (ORCID:\n),\nPete Philipson [aut] (ORCID: ),\nAndrea Jorgensen [ctb] (ORCID: ),\nRuwanthi Kolamunnage-Dona [aut] (ORCID:\n),\nPaula Williamson [ctb] (ORCID: ),\nDimitris Rizopoulos [ctb, dtc] (data/renal.rda, R/hessian.R, R/vcov.R),\nAlessandro Gasparini [aut] (ORCID:\n),\nMedical Research Council [fnd] (Grant number: MR/M013227/1)", "Maintainer": "Graeme L. 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